Spray Application for Cell Therapy inside hollow organs

  Left: In-vivo endoscopic spray application inside hollow organs (source: AME). Right: Highspeed-Visualization of an endoscopic sprays Reddemann, WSA, AME Left: In-vivo endoscopic spray application inside hollow organs (source: AME). Right: Highspeed-Visualization of an endoscopic sprays

The application of steam cell is a promising therapy for still remediless diseases. Although this procedure can realize its full potential only, if living stem cells are introduced at the source of disease with high concentration, no fully developed technique exists for in-vivo coating of hollow organs. Intravenous medication of steam cells is state of the art, instead.

In recent past, a novel innovative method was developed by the project partner AME, enabling the coating of hollow organs with living cells on the basis of an endoscopic spray with subsequent polymerization for the first time. In order to leverage this new therapy for future clinical operation on human beings, fundamental research on cell sprays and its influence on survival rates and growth rates of cells is inevitable. That way, a completely new research field -- cell sprays -- can be explored, which is largely unexplored up to date.

In context of this ERS Seed Fund project, a first time investigation of the influence of fluid dynamics on survival rates of cells will be done. This work will be the basis for future interdisciplinary fundamental research projects in this field.

 
Endoskop-Spray
Endoscope spray
 

Project details

Project duration

10/2012 – 09/2015

Funded by

ERS, RWTH Aachen University

Partner

  • Cardiovascular Tissue Engineering, Institute of Applied Medical Engineering (AME) Pauwelsstraße 20, 52074 Aachen, Chair: Univ.-Prof. Dr. med. Stefan Jockenhövel

Infrastructure

  • Labs

  • Custom made injection systems

  • Highspeed Visualization

  • Microscopy

  • Tensiometer

  • Viscosimeter